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Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration
Peter R van Dijk1, Femke Waanders2, Andreas Pasch3
1Department of Internal Medicine, University Medical Center Groningen, 9713 GZ, HPA AA41, Groningen, The Netherlands.
Therapeutic Advances in Endocrinology and Metabolism
|March 14, 2020
Summary
Intraperitoneal (IP) insulin administration in type 1 diabetes (T1DM) patients showed a longer calcification propensity time (T50) compared to subcutaneous (SC) insulin. This suggests a more favorable calcification profile with IP insulin.
Area of Science:
- Cardiovascular Health
- Metabolic Disorders
- Biochemistry
Background:
- Serum calcification propensity, measured by T50 test, is a determinant of cardiovascular disease.
- The intraperitoneal (IP) route of insulin administration may offer physiological advantages over the subcutaneous (SC) route in type 1 diabetes (T1DM).
Purpose of the Study:
- To investigate the effect of IP versus SC insulin administration on calcification propensity in T1DM patients.
- To determine if IP insulin influences T50 test results, indicating changes in calcium propensity.
Main Methods:
- Prospective, observational case-control study.
- Analysis of 181 T1DM patients (39 IP, 142 SC) at baseline and 26 weeks.
- Multivariable analyses to identify factors related to T50 concentrations.
Main Results:
- IP insulin group had a significantly longer geometric mean T50 (367 min) compared to the SC insulin group (352 min).
- The difference in T50 was -15 minutes in favor of IP treatment.
- Higher age, triglycerides, and phosphate levels were inversely related to T50.
Conclusions:
- IP insulin administration is associated with a more favorable calcification propensity time in T1DM patients compared to SC insulin.
- Further research is needed to confirm if this improved calcification profile translates to better cardiovascular outcomes.
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