Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gas Exchange and Transport01:20

Gas Exchange and Transport

76.2K
Gas exchange, the intake of molecular oxygen (O2) from the environment and the outflow of carbon dioxide (CO2) into the environment, is necessary for cellular function. Gas exchange during respiration occurs largely via the movement of gas molecules along pressure gradients. Gas travels from areas of higher partial pressure to areas of lower partial pressure. In mammals, gas exchange occurs in the alveoli of the lungs, which are adjacent to capillaries and share a membrane with them.
76.2K
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

1.6K
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
1.6K
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

377
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
377
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

671
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
671
Breathing01:05

Breathing

63.9K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
63.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heterogeneous Causes of Acute Respiratory Distress Syndrome Correlate With Distinct Peripheral Polyunsaturated Fatty Acid Metabolites.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Genomic surveillance of human metapneumovirus in the United States, 2010-2025.

The Journal of infectious diseases·2026
Same author

Global knockout of melanoma differentiation-associated protein 5 protects mice from chronic hypoxia/SU5416-induced pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology·2026
Same author

Lung microbiome predictors of epigenetic aging and potential associations with smoking and electronic cigarette use.

Clinical epigenetics·2026
Same author

Sustainable Business Models in Artificial Intelligence-Integrated Nursing: A Qualitative Study of Opportunities and Risks.

Nursing & health sciences·2026
Same author

Balancing Profit and Patient-Centredness: Nurses' Perspectives on Artificial Intelligence Adoption in Healthcare Businesses.

Journal of evaluation in clinical practice·2026

Related Experiment Video

Updated: Dec 26, 2025

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
09:54

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

2.2K

Circulating Gasdermin-D in Critically Ill Patients.

Elie Homsy1, Srabani Das2, Paul Consiglio2

  • 1Division of Pulmonary Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH.

Critical Care Explorations
|March 14, 2020
PubMed
Summary
This summary is machine-generated.

This study found elevated levels of active gasdermin-D in microparticles from critically ill sepsis patients, suggesting its role in organ dysfunction. These findings highlight gasdermin-D as a potential biomarker for sepsis.

Keywords:
caspase-1gasdermin-Dmicroparticlemonocytesepsis

More Related Videos

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

3.0K
Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

3.7K

Related Experiment Videos

Last Updated: Dec 26, 2025

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
09:54

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

2.2K
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

3.0K
Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

3.7K

Area of Science:

  • Immunology and Critical Care Medicine
  • Molecular Mechanisms of Inflammation

Background:

  • Sepsis involves a dysfunctional immune response leading to organ failure.
  • Gasdermin-D activation is a critical step in pyroptosis and organ dysfunction during sepsis.

Purpose of the Study:

  • To investigate the presence of active gasdermin-D in critically ill patients.
  • To explore the association between gasdermin-D levels and clinical outcomes in sepsis.

Main Methods:

  • Prospective pilot study involving critically ill patients and healthy donors.
  • Isolation and analysis of microparticles from plasma using ultracentrifugation and immunoblotting.
  • Quantification of gasdermin-D and exosomal markers (CD63, CD14, CD69) via densitometry.

Main Results:

  • No significant active gasdermin-D was detected in healthy volunteers or non-septic critically ill patients.
  • Elevated levels of active gasdermin-D were observed in microparticles from septic patients.
  • Positive correlations found between active gasdermin-D and monocyte/exosomal markers (CD63, CD14, CD69).

Conclusions:

  • This study is the first to demonstrate circulating active gasdermin-D in intensive care unit (ICU) sepsis patients.
  • Findings suggest active gasdermin-D in sepsis is encapsulated within exosomes derived from activated monocytes.
  • Further clinical characterization of active gasdermin-D in sepsis is warranted.