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Updated: Dec 26, 2025
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Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
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Neurogenic lower urinary tract dysfunction predicts prognosis in patients with multiple system atrophy
Tianying Xing1, Jinghong Ma2, Chunsong Jia1
1Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing, 100045, China.
Summary
Neurogenic lower urinary tract dysfunction in multiple system atrophy (MSA) predicts outcomes. A high bladder contractility index (BCI) indicates better survival, while urinary incontinence suggests a poorer prognosis.
Area of Science:
- Neurology
- Urology
Background:
- Multiple system atrophy (MSA) is a progressive neurodegenerative disorder.
- Neurogenic lower urinary tract dysfunction (NLUTD) is common in MSA patients.
- Urodynamic parameters may offer prognostic insights.
Purpose of the Study:
- To determine if NLUTD and urodynamic parameters predict outcomes in MSA patients.
- To investigate the prognostic value of bladder contractility index (BCI) and urinary incontinence.
Main Methods:
- Retrospective study of 70 MSA patients undergoing urodynamic studies.
- Evaluation of detrusor contractility using BCI and Schäfer nomogram.
- Survival data acquired via telephone follow-up and analyzed using Cox regression.
Main Results:
- MSA-P subtype showed lower BCI compared to MSA-C.
- Mean survival time for MSA patients was 5.4 years.
- BCI correlated with survival from baseline and overall survival.
- Urinary incontinence predicted shortened overall survival.
Conclusions:
- Detrusor contractility, assessed by BCI, is a prognostic marker in MSA.
- Higher BCI values are associated with improved survival.
- Urinary incontinence is a predictor of reduced survival in MSA patients.
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