Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

792
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
792
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

189
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
189
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

166
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
166
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

123
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
123
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

284
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
284

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated techno-economic and life cycle assessment of 3-hydroxypropionic acid bioproduction from a glycerol-molasses blend.

Bioresource technology·2026
Same author

Dystonia in Parkinson's disease: Clinical characteristics and predictors of treatment response.

Parkinsonism & related disorders·2026
Same author

Outcomes in provisional one-stent versus dedicated two-stent coronary bifurcation stenting techniques: a systematic review and meta-analysis.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology·2026
Same author

Interrelationship Between Depression, Unhealthy Behavior, and Non-Alcoholic Fatty Liver Disease in the United States of America.

American journal of lifestyle medicine·2026
Same author

Multiparametric MRI Radiomics for the Prediction of Histologic Grade in Bladder Cancer.

Indian journal of surgical oncology·2026
Same author

Stroke-induced gut microbiome dysbiosis accelerates Alzheimer's disease progression.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026

Related Experiment Video

Updated: Dec 26, 2025

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

27.6K

Association Between Obesity and Cardiovascular Outcomes: Updated Evidence from Meta-analysis Studies.

Alok Kumar Dwivedi1, Pallavi Dubey2, David P Cistola3

  • 1Division of Biostatistics & Epidemiology, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, 5001 El Paso Drive, El Paso, TX, 79905, USA. alok.dwivedi@ttuhsc.edu.

Current Cardiology Reports
|March 14, 2020
PubMed
Summary

Obesity increases cardiovascular disease (CVD) risk in the general population. However, the relationship between body mass index (BMI) and mortality is complex in patients with existing heart conditions, requiring tailored interventions.

Keywords:
All-cause mortalityBody mass indexCardiovascular diseaseHeart diseaseObesityOverweight

More Related Videos

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.3K
Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

370

Related Experiment Videos

Last Updated: Dec 26, 2025

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

27.6K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.3K
Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

370

Area of Science:

  • Cardiology
  • Public Health
  • Metabolic Health

Background:

  • Rising global prevalence of obesity and cardiovascular disease (CVD).
  • Conflicting findings in studies on adiposity and CVD outcomes.
  • Complexity of obesity-CVD interplay in general and specific populations.

Purpose of the Study:

  • To review updated evidence on the association between obesity and CVD events.
  • To elucidate the complex relationship between body mass index (BMI) and cardiovascular outcomes.
  • To identify risk stratification factors like cardiac respiratory fitness (CRF) and metabolic health.

Main Methods:

  • Review of meta-analysis studies.
  • Analysis of updated evidence on obesity and CVD events.
  • Examination of BMI associations with mortality across different patient groups.

Main Results:

  • Obesity/high BMI linked to increased CVD events and mortality in the general population.
  • CRF and metabolic health status stratify CVD risk.
  • U-shaped BMI-mortality association in diabetes, hypertension, and coronary artery disease.
  • Reverse J-shaped BMI-mortality association in severe heart disease/cardiac surgery patients.

Conclusions:

  • Obesity prevention is crucial for the general population.
  • BMI-outcome relationship is complex in patients with diagnosed cardiovascular diseases or diabetes.
  • Further research needed on longitudinal BMI changes and mortality in severe heart disease patients.
  • Integrated interventions (weight management, CRF, metabolic health, avoiding weight loss) are recommended for improved CVD outcomes.