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Related Experiment Video

Updated: Dec 26, 2025

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
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An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

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Genomic Subtyping in Bladder Cancer.

Tuomas Jalanko1,2, Joep J de Jong3, Ewan A Gibb4

  • 1Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada.

Current Urology Reports
|March 14, 2020
PubMed
Summary
This summary is machine-generated.

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Genomic characterization reveals at least six molecular subtypes of bladder cancer, each with distinct profiles and prognoses. Clinical implementation of these genomic subtypes requires further validation and integrative analysis.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Molecular characterization of cancer is crucial for understanding oncogenesis and clinical prognosis.
  • It also facilitates the development of biomarkers and targeted treatments for various cancers.

Purpose of the Study:

  • To review the current literature on the genomic characterization of bladder cancer.
  • To assess the progress in implementing genomic findings into clinical practice for bladder cancer management.

Main Methods:

  • Literature review of studies on genomic characterization of bladder cancer.
  • Analysis of identified molecular subtypes and their genomic/transcriptomic profiles.

Main Results:

  • Bladder cancers exhibit significant molecular diversity with a high mutation rate.
Keywords:
Bladder cancerGenomic analysisImmunotherapyMolecular subtypingMutationsNeoadjuvant chemotherapy

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Last Updated: Dec 26, 2025

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  • At least six molecular subtypes have been identified: luminal-papillary, luminal-unstable, luminal non-specified, basal-squamous, neuroendocrine-like, and stroma-rich.
  • These subtypes possess distinct genomic and transcriptomic profiles, correlating with different prognoses.

    • Conclusions:

    • Genomic subtyping of bladder cancer is a promising area with identified molecular subtypes.
    • Prospective trials are ongoing to validate the clinical applicability of these subtypes.
    • Further integrative analyses are necessary before routine clinical implementation of genomic subtyping.