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Related Experiment Videos

Possible linkage between alcoholism and esterase-D.

V L Tanna1, A F Wilson, G Winokur

  • 1Veterans Administration Medical Center, Northport, New York 11768.

Journal of Studies on Alcohol
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

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This study investigated genetic links to alcoholism. A significant linkage was found between alcoholism and the esterase-D (ESD) marker on chromosome 13q, suggesting a potential genetic basis for the disorder.

Area of Science:

  • Genetics
  • Psychiatry
  • Molecular Biology

Background:

  • Alcoholism is a complex disorder with suspected genetic contributions.
  • Previous genetic studies have yielded mixed results, necessitating further investigation.

Purpose of the Study:

  • To investigate the association and linkage between alcoholism and polymorphic marker loci.
  • To identify specific genetic markers associated with alcoholism in familial cases.

Main Methods:

  • Analyzed 42 families using sib-pair and lod score linkage analyses.
  • Examined 30 polymorphic marker loci, focusing on the esterase-D (ESD) locus.
  • Alcoholism was treated as an independent disorder to avoid confounding factors.

Main Results:

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  • No significant allelic associations were found between alcoholism and the studied markers.
  • A significant difference in genes identical by descent was observed in sib-pair linkage analysis for the esterase-D (ESD) marker (p <= .01).
  • Lod score analysis indicated strong evidence for linkage between alcoholism and the ESD locus on chromosome 13q (odds of 44:1).

Conclusions:

  • The esterase-D (ESD) marker on chromosome 13q is a potential candidate locus for a gene influencing alcoholism.
  • Further research is warranted to confirm the linkage and elucidate the specific genetic mechanisms involved in alcoholism.