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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

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Looking into the next decade of antithrombotic therapy for patients with atrial fibrillation and percutaneous

Benjamin E Peterson1, Deepak L Bhatt2

  • 1Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Journal of Thrombosis and Thrombolysis
|March 14, 2020
PubMed

Insights

Managing antithrombotic therapy for atrial fibrillation patients undergoing percutaneous coronary intervention remains challenging. This review covers historical and novel anticoagulation strategies to prevent thrombotic events.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) face elevated risks of thrombotic events.
  • Optimizing antithrombotic therapy in this high-risk population is a significant clinical challenge.

Purpose of the Study:

  • To review the evolution of antithrombotic strategies for AF patients undergoing PCI.
  • To discuss current and emerging treatment regimens, including novel oral anticoagulants (NOACs).

Main Methods:

  • Literature review of historical and recent clinical trials.
  • Analysis of antithrombotic therapy development, from warfarin triple therapy to NOAC-based dual therapy.

Main Results:

  • Warfarin triple therapy was historically standard but associated with bleeding risks.
  • Transition to dual therapy with warfarin and P2Y12 inhibitors offered alternatives.
  • Emergence of NOACs has led to new dual and triple therapy regimens with improved safety profiles.

Conclusions:

  • Antithrombotic therapy for AF patients undergoing PCI has evolved significantly.
  • Current practice favors NOAC-based regimens, balancing efficacy and safety.
  • Ongoing research aims to further refine optimal antithrombotic strategies.

Keywords:
AnticoagulationAntiplatelet therapyAtrial fibrillationNon-vitamin K oral anticoagulantsPercutaneous coronary intervention

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