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Relaxation time constant based optical coherence elastography.

Duo Zhang¹, Chunhui Li¹, Zhihong Huang¹

¹School of Science and Engineering, University of Dundee, Dundee, Scotland, UK.

Journal of Biophotonics

|March 14, 2020

Summary

This summary is machine-generated.

This study introduces relative relaxation time constant (RTC) mapping using optical coherence elastography (OCE) to visualize soft tissue properties. RTC mapping provides new insights into tissue mechanics for potential disease diagnosis.

Keywords:

Kelvin-Voigt fractional derivative optical coherence elastography optical coherence tomography relaxation time constant

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Area of Science:

Biomedical Optics
Medical Imaging
Biophysics

Background:

Assessing soft tissue mechanical properties is crucial for disease diagnosis.
Existing elastography methods primarily focus on elasticity, often neglecting viscosity.

Purpose of the Study:

To develop and validate a novel method for visualizing the relative relaxation time constant (RTC) in soft tissues.
To integrate RTC visualization into optical coherence elastography (OCE) for comprehensive mechanical property assessment.

Main Methods:

Proposed a forced vibration model correlating RTC with the axial gradient of periodic vibration phase.
Utilized phase-sensitive optical coherence tomography (PhS-OCT) for phase data acquisition.
Validated the model using isotropic and double-layered phantoms and tested on focused ultrasound-treated chicken breast tissue.

Main Results:

Successfully visualized 2D and 3D RTC maps in soft tissues.
RTC mapping revealed internal mechanical differences correlating with conventional strain mapping.
Cross-validation confirmed results against indentation tests and traditional strain elastography.

Conclusions:

RTC mapping via OCE offers a new approach to assess both elasticity and viscosity in soft tissues.
This technique provides a comprehensive mechanical characterization potentially useful for disease diagnosis.
RTC mapping shows promise as a novel biomarker for future clinical applications.