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Related Experiment Video

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Tissue Preparation and Immunostaining of Mouse Sensory Nerve Fibers Innervating Skin and Limb Bones

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What Every Neuropathologist Needs to Know: Peripheral Nerve Biopsy.

Rati Chkheidze¹, Peter Pytel²

¹From the Department of Pathology, UT Southwestern Medical Center, Dallas, Texas.

Journal of Neuropathology and Experimental Neurology

|March 14, 2020

Summary

Peripheral nerve biopsy aids diagnosis when other methods fail for complex neuropathies. Pathologic examination of nerve biopsies remains a valuable tool for identifying causes of peripheral neuropathy.

Keywords:

Biopsy Nerve Peripheral

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Area of Science:

Neurology
Pathology

Background:

Peripheral neuropathy is a common condition with diverse causes.
Diagnosis typically relies on clinical evaluation, history, lab tests, genetic testing, and electrophysiology.
However, some cases require advanced diagnostic procedures.

Purpose of the Study:

To highlight the continued clinical utility of peripheral nerve biopsy.
To emphasize its role in diagnosing challenging peripheral neuropathy cases.

Main Methods:

Review of diagnostic approaches for peripheral neuropathy.
Discussion of the role and interpretation of peripheral nerve biopsy.
Focus on specimen triage and key pathological assessment criteria.

Main Results:

Peripheral nerve biopsy is crucial for atypical or rapidly progressive neuropathies.
It provides a definitive diagnosis when other methods are inconclusive.
Pathologic assessment involves evaluating specimen adequacy, inflammation, vascular changes, amyloid, and axonal/myelin integrity.

Conclusions:

Peripheral nerve biopsy remains an indispensable diagnostic tool in neurology.
A systematic approach to nerve biopsy interpretation is essential for clinical utility.
It offers valuable insights for diagnosing and managing peripheral neuropathies.