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Related Concept Videos

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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Related Experiment Video

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The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
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Thyroid Function and Sarcopenia: Results from the ELSA-Brasil Study.

Claudia Szlejf1, Claudia K Suemoto1,2, Carolina C P S Janovsky1

  • 1Center for Clinical and Epidemiological Research, Hospital Universitário, University of São Paulo, São Paulo, Brazil.

Journal of the American Geriatrics Society
|March 14, 2020
PubMed
Summary
This summary is machine-generated.

Subtle thyroid hormone changes, not overt disease, are linked to sarcopenia in older adults. Thyrotropin (TSH) showed a U-shaped association with sarcopenia and low muscle strength in older individuals.

Keywords:
muscle strengthsarcopeniathyrotropinthyroxinetriiodothyronine

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Area of Science:

  • Gerontology
  • Endocrinology
  • Musculoskeletal Health

Background:

  • Subclinical thyroid dysfunction is common in older adults.
  • Sarcopenia, characterized by low muscle mass and strength, is a significant geriatric syndrome.
  • The relationship between subtle thyroid hormone variations and sarcopenia remains unclear in individuals without overt thyroid disease.

Purpose of the Study:

  • To examine the association between subclinical thyroid disease, thyroid hormone levels, and sarcopenia in community-dwelling middle-aged and older adults.
  • To investigate the link between thyrotropin (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) levels and the defining components of sarcopenia.

Main Methods:

  • Cross-sectional study of 6974 participants (aged ≥50 years) from the ELSA-Brasil cohort.
  • Thyroid function assessed via serum TSH, FT4, and FT3 levels, categorized into euthyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism.
  • Sarcopenia evaluated using bioelectrical impedance analysis for muscle mass and handgrip strength for muscle strength, defined by NIH criteria.

Main Results:

  • Subclinical thyroid dysfunction was not significantly associated with sarcopenia or its components.
  • Among older adults (≥65 years), TSH exhibited a U-shaped association with sarcopenia and low muscle strength.
  • Higher FT3 levels were negatively associated with muscle mass in both middle-aged and older adults.

Conclusions:

  • Subtle alterations in thyroid hormone levels, rather than overt subclinical thyroid dysfunction, are associated with sarcopenia and its components in adults without overt thyroid disease.
  • These findings highlight the importance of monitoring thyroid hormone levels in the context of age-related muscle decline.