Long-Term Alleviation of Parkinsonian Resting Tremor Using Wireless Optogenetic Nanonetworks

Resting tremor is one of the major symptoms of Parkinson's disease, which causes havoc in motor functions of the body, has its genesis in communication impairments in the subthalamic nucleus of the basal ganglia. The modern sophisticated surgical treatments, including electrical deep brain stimulation do not yield satisfactory results due to their inability to provide long-term cure and minimize side effects, such as discomfort and increased infection rates. In this work, we propose a novel system based on the emerging communication technology of wireless optogenetic networks of neural dusts to provide a long-term solution for the alleviation of resting tremor. Interfaced with neural dusts, each of the subthalamic nucleus neurons can be controlled and stimulated by the ultrasonic waves which are transmitted from a single/multiple subdural transducer(s) that are placed in the dura mater of the brain. Moreover, in order to address the challenging tasks of charging and addressing each of the neural dusts, we propose a protocol, named as Single Time Instant addressing Protocol, which outperforms the state-of-the-art parallel charging protocol. The basic idea of our protocol is that it selects most frequently occurring spike patterns in a single time instant and assigns the pattern with an ultrasonic frequency. With the improved efficiency of Single Time Instant addressing Protocol validated with empirical datasets, the proposed system is expected to revolutionize the way of treatment of parkinsonian resting tremor.