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Blood pressure targets in chronic kidney disease: an update on the evidence

Dominique Guerrot1, Jelmer K Humalda

  • 1Normandie University, UNIROUEN, INSERM U1096, FHU REMOD-VHF Nephrology Department, Rouen University Hospital, Rouen, France Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.

Current Opinion in Nephrology and Hypertension
|March 14, 2020
PubMed

Insights

Defining optimal blood pressure targets is crucial for managing hypertension in chronic kidney disease patients. Recent trials offer insights but yield differing guideline recommendations, highlighting ongoing controversy.

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Management

Background:

  • Hypertension is a primary modifiable risk factor for cardiovascular events, mortality, and a direct cause of chronic kidney disease (CKD).
  • Establishing optimal blood pressure (BP) targets in CKD patients is critical for improving outcomes and reducing disease progression.

Purpose of the Study:

  • To review current evidence on blood pressure targets for patients with chronic kidney disease.
  • To summarize areas of controversy and differing interpretations of recent trial data regarding BP management in CKD.

Main Methods:

  • Review of recent clinical trials and post-hoc analyses comparing different blood pressure targets in patients with chronic kidney disease.
  • Analysis of current hypertension guidelines and their recommendations for CKD management.

Main Results:

  • Recent trials provide valuable data on the impact of high blood pressure in CKD.
  • Discrepancies in trial interpretations have led to varied recommendations in current clinical guidelines.
  • Significant controversy persists regarding the optimal blood pressure targets for individuals with chronic kidney disease.

Conclusions:

  • The optimal blood pressure target in patients with chronic kidney disease remains a subject of ongoing debate.
  • Further research and consensus are needed to refine management strategies for hypertension in CKD.
  • Current guidelines reflect differing interpretations of available evidence, necessitating careful consideration in clinical practice.
Abstract

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