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Relationship between cardio-ankle vascular index and obstructive coronary artery disease

Divya Birudaraju1, Lavanya Cherukuri, April Kinninger

  • 1Department of Cardiology, Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance, California, USA.

Coronary Artery Disease
|March 14, 2020
PubMed

Insights

Cardio-ankle vascular index (CAVI) effectively assesses arterial stiffness and correlates with coronary atherosclerosis. This noninvasive measure can serve as a valuable screening tool for early detection of obstructive coronary artery disease.

Area of Science:

  • Cardiovascular Medicine
  • Diagnostic Imaging
  • Vascular Biology

Background:

  • Cardio-ankle vascular index (CAVI) is a noninvasive method to assess arterial stiffness in the aorta and legs.
  • Arterial stiffness measured by CAVI reflects the degree of coronary atherosclerosis.
  • CAVI is clinically used to evaluate patients with coronary artery disease (CAD), stroke, and those at risk.

Purpose of the Study:

  • To evaluate the relationship between CAVI and obstructive coronary artery disease (CAD).
  • To determine if CAVI can predict severe coronary stenosis or high coronary artery calcium (CAC) scores.

Main Methods:

  • 285 individuals referred for Coronary Artery Calcium (CAC) scoring and coronary computed tomography angiography (CCTA) were enrolled.
  • CAVI measurements were performed on the same day as CCTA.
  • Obstructive CAD was defined as severe stenosis (>50%) or CAC >100.

Main Results:

  • CAVI showed significant correlation with both CAC score (r=0.44) and severe coronary stenosis (r=0.43).
  • A CAVI cutoff of 7.8 demonstrated optimal sensitivity and specificity for detecting obstructive CAD.
  • CAVI >7.8 was significantly associated with obstructive CAD (OR=4.60) and CAC >100 (OR=6.96).

Conclusions:

  • CAVI is a reliable indicator of coronary atherosclerosis.
  • CAVI can be utilized as a screening tool for early identification of subclinical atherosclerosis.
  • CAVI may help optimize the management of patients at risk for cardiovascular disease.
Abstract

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