Related Experiment Video
Updated: Dec 26, 2025

Evaluation of Blood Lactate and Plasma Insulin During High-intensity Exercise by Antecubital Vein Catheterization
Published on: May 18, 2018
Sports Drink Intake Pattern Affects Exogenous Carbohydrate Oxidation during Running
Stephen A Mears1, Benjamin Boxer, David Sheldon
1School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UNITED KINGDOM.
Consuming carbohydrate sports drinks in larger, less frequent doses during endurance running enhances exogenous carbohydrate oxidation. This method did not lead to severe gastrointestinal discomfort in well-trained runners.
Area of Science:
- Exercise Physiology
- Sports Nutrition
- Metabolic Research
Background:
- Optimizing fuel utilization during prolonged exercise is crucial for athletic performance.
- The pattern of carbohydrate intake can influence substrate oxidation and gastrointestinal comfort.
- Understanding how different ingestion strategies affect energy metabolism is vital for sports science.
Purpose of the Study:
- To investigate the impact of carbohydrate sports drink ingestion patterns on exogenous carbohydrate oxidation rates.
- To assess the effect of different drinking frequencies on gastrointestinal (GI) comfort during prolonged running.
- To compare the metabolic and subjective responses to two distinct carbohydrate feeding strategies.
Main Methods:
- Twelve male runners performed 100-minute submaximal running trials at 70% V˙O2peak.
- Participants consumed 1L of a 10% dextrose solution (enriched with [U-C] glucose) either as 200 mL every 20 min (CHO-20) or 50 mL every 5 min (CHO-5).
- Exogenous carbohydrate oxidation was measured using isotope-labeled glucose, alongside blood glucose and insulin levels, and subjective GI comfort ratings.
Main Results:
- Exogenous carbohydrate oxidation rates were significantly higher (23% on average) with the CHO-20 (200 mL every 20 min) strategy.
- Peak exogenous carbohydrate oxidation was also elevated in the CHO-20 trial compared to CHO-5.
- No significant differences were observed in total carbohydrate oxidation, endogenous carbohydrate oxidation, serum glucose, insulin concentrations, or severe GI discomfort between the two ingestion patterns.
Conclusions:
- Ingesting carbohydrate solutions in larger volumes at less frequent intervals enhances exogenous carbohydrate oxidation during prolonged submaximal running.
- Neither the CHO-20 nor the CHO-5 ingestion pattern led to severe gastrointestinal discomfort in well-trained runners.
- This suggests that a less frequent, larger-volume intake strategy may be beneficial for maximizing carbohydrate utilization without compromising GI comfort.
Related Concept Videos
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Muscle Recovery and Fatigue
Outcomes of Glycolysis
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be...
Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...

