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Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
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Acute Pancreatitis I: Introduction

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Related Experiment Video

Updated: Dec 26, 2025

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

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Published on: January 17, 2025

An Overview on Primary Sclerosing Cholangitis.

Cătălina Vlăduţ^1,2, Mihai Ciocîrlan^1,2, Dana Bilous²

¹Department of Gastroenterology, Prof Dr Agrippa Ionescu Clinical Emergency Hospital, 7000 Bucharest, Romania.

Journal of Clinical Medicine

|March 15, 2020

Summary

Primary sclerosing cholangitis (PSC) is a progressive liver disease with unclear pathogenesis. Diagnosis relies on cholangiography, and management focuses on invasive treatments due to limited effective therapies.

Keywords:

cholangiography choleangiectasias liver transplant primary sclerosing cholangitis

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Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

Published on: March 14, 2020

Area of Science:

Hepatology
Gastroenterology
Immunology

Background:

Primary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease leading to fibrosis and cirrhosis.
Its pathogenesis likely involves autoimmune, environmental, and ischemic factors.
PSC significantly increases the risk of cholangiocarcinoma and colorectal adenocarcinoma.

Purpose of the Study:

To summarize the current understanding of PSC diagnosis, complications, and management.
To highlight the limitations of existing treatments and the need for further research.

Main Methods:

Diagnosis primarily involves cholangiography (ERCP, MRCP, PTC) revealing characteristic "beaded" biliary strictures.
Screening for complications includes annual clinical/biochemical assessments, ultrasounds, and colonoscopies.
Management relies on invasive procedures like liver transplantation and endoscopy due to lack of curative medical treatments.

Main Results:

Ursodeoxycholic acid shows limited benefit and is not recommended for early PSC.
Current treatments do not significantly impact the risk of cholangiocarcinoma, liver transplant, or mortality.
Ongoing research explores molecular-targeted therapies for PSC.

Conclusions:

PSC is a complex liver disease requiring vigilant monitoring and management of complications.
Effective medical treatments are lacking, emphasizing the need for novel therapeutic strategies.
Further research into targeted therapies holds promise for improving PSC outcomes.