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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Positron Emission Tomography01:29

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
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Advances in simultaneous PET/MR for imaging neuroreceptor function.

Christin Y Sander1, Hanne D Hansen1,2, Hsiao-Ying Wey1

  • 1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, MA, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|March 15, 2020
PubMed
Summary
This summary is machine-generated.

Simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) offers new insights into brain function and disease by combining molecular and anatomical data. This approach enhances understanding of neurotransmitter systems and their dynamics in the living human brain.

Keywords:
Dopamineopioidpharmacologyserotoninsimultaneous PET/MRI

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Biochemistry

Background:

  • Hybrid imaging, particularly PET/MRI, is a powerful tool for studying brain function.
  • It allows for the investigation of neurobiology, disease-related changes, and intervention responses.
  • PET/MRI provides insights into central nervous system biochemical processes, linking molecular targets with brain function.

Purpose of the Study:

  • To review the application of simultaneous PET/MRI in neuroscience.
  • To highlight the strengths of PET/MRI in dynamic measurements during interventions.
  • To focus on functional studies of neurotransmitter and receptor systems.

Main Methods:

  • Leveraging simultaneous PET/MRI for dynamic measurements.
  • Analyzing multi-modal imaging signals during pharmacological, physiological, or behavioral challenges.
  • Reviewing experimental design and data analysis for dynamic PET/MRI studies.

Main Results:

  • PET/MRI enables measurement of dynamic changes in imaging signals.
  • Studies focus on dopamine, opioid, serotonin, and glutamate systems.
  • Interventions are used to alter neuroreceptor activity and neurotransmitter release.

Conclusions:

  • Simultaneous PET/MRI synergistically expands knowledge of the living human brain's molecular and functional dynamics.
  • Appropriate study design and interventions are crucial for maximizing PET/MRI potential.
  • Future opportunities for simultaneous PET/MRI in neuroscience are promising.