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Presentations and Outcomes of Thyroid Storm

Muhammad Shahid1, Zareen Kiran1, Aqiba Sarfraz2

  • 1National Institute of Diabetes & Endocrinology (NIDE), Dow University of Health Sciences (Ojha Campus) Karachi, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|March 15, 2020
PubMed

Insights

Thyroid storm patients in Karachi had a high mortality rate of 87.5%. Infections were the most frequent comorbidity, highlighting the critical nature of this endocrine emergency.

Area of Science:

  • Endocrinology
  • Internal Medicine
  • Critical Care Medicine

Background:

  • Thyroid storm is a life-threatening endocrine emergency.
  • Limited data exists on thyroid storm characteristics and outcomes in Pakistan.

Purpose of the Study:

  • To describe the clinical features and outcomes of thyroid storm patients.
  • To identify factors associated with mortality in thyroid storm.

Main Methods:

  • Retrospective review of thyroid storm patients (December 2018 - May 2019).
  • Inclusion criteria: Age 18-70 years, fulfilling Burch-Wartofsky criteria.
  • Data collected: Demographics, clinical presentation, comorbidities, laboratory findings.

Main Results:

  • Eight patients were included; 62.5% were female, mean age 43 years.
  • Infections were the most common comorbidity (62.5%), followed by cardiovascular (37.5%) and gastrointestinal (25%) diseases.
  • In-hospital mortality rate was 87.5% (7 out of 8 patients).

Conclusions:

  • Thyroid storm in Karachi is associated with extremely high mortality.
  • Infections are a significant precipitating factor.
  • Urgent and aggressive management is crucial for improving outcomes.

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