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Related Experiment Video

Updated: Dec 26, 2025

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Gene Polymorphisms Affecting Erectile Dysfunction.

Taymour Mostafa¹, Mai Taymour²

¹Andrology & Sexology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Sexual Medicine Reviews

|March 15, 2020

Summary

Genetic polymorphisms may contribute to erectile dysfunction (ED). This review highlights key genes like eNOS and ACE, suggesting further research is needed to clarify their role in ED development.

Keywords:

Erectile Dysfunction Genes Polymorphisms Sexual Disorders Sexual Health

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Published on: June 6, 2018

Area of Science:

Genetics and Urology
Molecular Biology
Sexual Health Research

Background:

Erectile dysfunction (ED) has multifactorial causes including psychological, neurological, hormonal, and vascular factors.
The potential genetic underpinnings of ED have not been extensively explored.

Approach:

A systematic review of studies published until January 2020 was conducted.
Searches were performed across major databases including PubMed, Scopus, and EMBASE.
Keywords focused on sexual health, genes, erectile dysfunction, polymorphisms, and cavernous tissues.

Key Points:

50 studies involving 10,174 men with ED and 6,891 controls were analyzed.
Significant gene polymorphisms associated with ED include endothelial nitric oxide synthase (eNOS), angiotensin-converting enzyme (ACE), and androgen receptor (AR).
Other implicated genes include GNB3, MTHFR, VEGF, TGFB1, PCSK9, ARG1, DRD2, DRD4, DDAH, and HNF4A.

Conclusions:

While genetic variations show varied associations with ED, their role warrants further investigation.
Additional research is recommended to fully elucidate the genetic contribution to erectile dysfunction.