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Updated: Dec 26, 2025

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

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Gut microbiota and aging-A focus on centenarians.

Adriana Florinela Cӑtoi¹, Andreea Corina², Niki Katsiki³

¹Pathophysiology Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Biochimica Et Biophysica Acta. Molecular Basis of Disease

|March 15, 2020

Summary

The gut microbiota (GM) plays a role in aging and longevity. Specific GM compositions may contribute to a longer lifespan and resistance to age-related diseases.

Keywords:

Aging Centenarians Gut microbiota Prebiotics Probiotics Synbiotics

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Area of Science:

Microbiology
Gerontology
Immunology

Background:

The gut microbiota (GM) is a dynamic entity influenced by host aging.
Aging involves senescence, immunosenescence, and inflammaging, contributing to age-related diseases.
Centenarians exhibit unique adaptability, potentially linked to their GM.

Purpose of the Study:

To explore the association between gut microbiota and longevity.
To understand how GM composition influences resistance to age-related diseases.
To investigate the role of diet, prebiotics, probiotics, and synbiotics in modulating GM for longevity.

Main Methods:

Review of existing literature on gut microbiota and aging.
Analysis of studies focusing on centenarian gut microbiome.
Exploration of potential mechanisms linking GM to host healthspan and lifespan.

Main Results:

Longevity appears associated with specific gut microbiota profiles.
Certain GM compositions may confer resistance to age-related diseases.
Dietary interventions (prebiotics, probiotics, synbiotics) can modulate GM.

Conclusions:

The gut microbiota is a significant factor in aging and longevity.
Further research is needed to elucidate the precise mechanisms of GM-host interactions in extended lifespan.
Targeting GM may offer strategies to promote healthy aging and longevity.