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Related Experiment Video

Updated: Dec 26, 2025

Inducing Apical Periodontitis in Mice

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network.

Lu Sun^1,2,3, Mustafa Girnary⁴, Lufei Wang³

¹Department of Periodontology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

Journal of Immunology (Baltimore, Md. : 1950)

|March 15, 2020

Summary

This summary is machine-generated.

Interleukin-17 (IL-17) drives periodontitis inflammation, but Interleukin-10 (IL-10) can dampen this response. IL-10 mitigates IL-17 effects, potentially offering therapeutic strategies for periodontitis.

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Last Updated: Dec 26, 2025

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Published on: August 6, 2019

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

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Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

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Published on: February 16, 2016

Area of Science:

Immunology
Periodontology
Molecular Biology

Background:

Periodontitis involves complex inflammatory networks.
Immune profiling offers potential prognostic signatures for periodontitis.
The roles of specific cytokines like IL-17 and IL-10 in periodontitis require further elucidation.

Purpose of the Study:

To identify periodontitis-associated inflammatory expression networks.
To investigate the interplay between IL-17 and IL-10 in periodontitis pathogenesis.
To explore the cellular mechanisms underlying the IL-10-mediated dampening of IL-17 signaling.

Main Methods:

Principal component analysis of gingival crevicular fluid biomarkers.
In vitro stimulation of peripheral blood monocytic cells and macrophages with IL-17 and IL-10.
Murine models of periodontitis (Porphyromonas gingivalis-induced and ligature-induced) in wild-type and Il10-deficient mice.
Analysis of gene expression and immune cell phenotypes.

Main Results:

An IL-17-dominated inflammatory network associated with periodontitis was identified.
IL-10 mitigated CXCL5 and CXCL1 expression in IL-17-stimulated immune cells.
Il10-deficient mice exhibited increased bone loss, elevated IL-17 signaling, and an M1 macrophage phenotype.

Conclusions:

IL-17 is a key driver of the inflammatory network in periodontitis.
IL-10 exerts a dampening effect on excessive IL-17-mediated inflammation in periodontitis.
The protective effect of IL-10 involves modulation of innate immune cells, particularly macrophages, rather than gingival epithelial cells.