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Updated: Dec 26, 2025

Combined Conditional Knockdown and Adapted Sphere Formation Assay to Study a Stemness-Associated Gene of Patient-derived Gastric Cancer Stem Cells
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Gastrin Blocks Symmetric Stem-Cell Division and Gastric Tumorigenesis

    Cancer Discovery
    |March 15, 2020
    PubMed

    Insights

    Symmetric stem cell division, identified by the gastrin receptor (CCK2R), is associated with the development of gastric cancer. This finding offers new insights into cancer stem cell biology and gastric tumorigenesis.

    Area of Science:

    • Gastroenterology
    • Oncology
    • Stem Cell Biology

    Background:

    • Gastric cancer remains a significant global health challenge.
    • Stem cell behavior is increasingly recognized as crucial in cancer development.
    • The gastrin receptor (CCK2R) plays a role in gastrointestinal physiology.

    Purpose of the Study:

    • To investigate the role of stem cell division symmetry in gastric cancer.
    • To determine the association between gastrin receptor (CCK2R) expression and stem cell division patterns.
    • To explore potential therapeutic targets in gastric cancer based on stem cell characteristics.

    Main Methods:

    • Analysis of stem cell populations in gastric tissues.
    • Immunohistochemical staining for gastrin receptor (CCK2R) expression.
    • Microscopic evaluation of cell division symmetry (symmetric vs. asymmetric).
    • Correlation analysis between CCK2R positivity and division patterns.

    Main Results:

    • Stem cells positive for the gastrin receptor (CCK2R) were identified in gastric cancer samples.
    • A significant association was found between symmetric division of CCK2R-positive stem cells and gastric cancer.
    • Asymmetric division was less prevalent in CCK2R-positive stem cells within the tumor microenvironment.

    Conclusions:

    • Symmetric division of gastrin receptor (CCK2R)-expressing stem cells is a potential driver of gastric cancer.
    • Targeting CCK2R or modulating stem cell division symmetry may offer novel therapeutic strategies for gastric cancer.
    • Understanding stem cell dynamics is critical for advancing gastric cancer research.

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