Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Polygenic Traits01:18

Polygenic Traits

68.7K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
68.7K
Nature and Nurture01:10

Nature and Nurture

22.0K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.0K
Gene-Environment Interactions01:20

Gene-Environment Interactions

973
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
973
Human Genetics01:28

Human Genetics

1.3K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.3K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

36.6K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.6K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

911
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
911

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of Novel Genetic Risk Variants Associated With Early-Onset Ischemic Stroke in Taiwan.

Neurology·2026
Same author

Genetic evidence for the association between schizophrenia and obesity.

International journal of obesity (2005)·2026
Same author

Genetic evidence for the associations of sleep patterns with cognitive function in older adults: insights from polygenic scores in the Taiwan biobank.

European archives of psychiatry and clinical neuroscience·2026
Same author

Polygenic risk and air pollution trends in relation to type 2 diabetes: evidence from the Taiwan Biobank.

Diabetology & metabolic syndrome·2026
Same author

Integrating Polygenic Scores and Family History for Type 2 Diabetes Prediction in an East Asian Population: Insights From the Taiwan Biobank.

Diabetes·2025
Same author

Air pollution and accelerated epigenetic aging: Evidence from multiple epigenetic clocks in the Taiwan Biobank.

Journal of hazardous materials·2025

Related Experiment Video

Updated: Dec 26, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.1K

Genetic Architecture Associated With Familial Short Stature.

Ying-Ju Lin1,2, Chi-Fung Cheng1,3, Chung-Hsing Wang4

  • 1Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

The Journal of Clinical Endocrinology and Metabolism
|March 15, 2020
PubMed
Summary

A new polygenic risk score using 10 genetic markers accurately predicts familial short stature (FSS) risk in Han Chinese individuals. This score also correlates with a tendency for reduced height in the general population.

Keywords:
GWASHan Chinese ancestryfamilial short staturehuman heightpolygenic trait

More Related Videos

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.2K

Related Experiment Videos

Last Updated: Dec 26, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.1K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.2K

Area of Science:

  • Genetics
  • Human height
  • Pediatric endocrinology

Background:

  • Human height is a complex, inheritable trait influenced by multiple genes.
  • Familial short stature (FSS) is the most common form of short stature but is not well understood.
  • Understanding the genetic basis of FSS is crucial for accurate diagnosis and prediction.

Purpose of the Study:

  • To investigate the genetic profile of familial short stature (FSS).
  • To develop a polygenic risk predisposition score for predicting FSS risk.
  • To assess the score's association with height reduction tendencies.

Main Methods:

  • Genome-wide association studies (GWAS) were conducted on 1163 FSS participants of Han Chinese ancestry in Taiwan.
  • Bootstrapping subsampling was employed to identify genetic profiles.
  • A polygenic risk predisposition score was constructed using identified single nucleotide polymorphisms (SNPs).

Main Results:

  • Ten novel and 9 previously reported human height-related SNPs were identified as associated with FSS risk.
  • The developed polygenic risk predisposition score achieved an area under the curve of 0.940 for FSS risk prediction in the testing group.
  • The FSS polygenic risk score demonstrated an association with height reduction tendencies in the general population.

Conclusions:

  • A polygenic risk predisposition score comprising 10 genetic SNPs is effective for predicting FSS risk.
  • This score may also indicate a tendency for reduced height.
  • The findings contribute to understanding FSS risk in the Han Chinese population in Taiwan.