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Eosinophils in wound healing and epithelial remodeling: Is coagulation a missing link?
Mackenzie E Coden1, Sergejs Berdnikovs1
1Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Journal of Leukocyte Biology
|March 15, 2020
Summary
Eosinophils partner with the coagulation system to aid in tissue repair and epithelial remodeling. This review explores their mechanistic links in injury, inflammation, and diseases like cancer and heart disease.
Area of Science:
- Immunology
- Hematology
- Cell Biology
Background:
- Eosinophils are implicated in wound healing and epithelial remodeling, but mechanisms are unclear.
- Eosinophils interact with the coagulation and fibrinolytic systems, influencing hemostasis and tissue repair.
Purpose of the Study:
- To review the mechanistic links between eosinophils and coagulation.
- To explore eosinophil-coagulation interactions in epithelial injury, repair, and disease.
Main Methods:
- Literature review of studies on eosinophils and coagulation.
- Analysis of eosinophil-derived factors in coagulation and fibrinolysis.
- Examination of disease associations.
Main Results:
- Eosinophils produce key coagulation factors (tissue factor, thrombin) and fibrinolytic factors (plasminogen).
- Eosinophils interact with fibrinogen and the urokinase system, modulating coagulation and fibrinolysis.
- Associations exist between eosinophils and dysregulated coagulation in various diseases.
Conclusions:
- Eosinophils play a significant, often overlooked, role in epithelial injury and repair via coagulation system interactions.
- Understanding these mechanisms is crucial for addressing associated inflammatory diseases and cancer.
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