Related Experiment Video
Updated: Dec 26, 2025
10:42
Generation and Culturing of Primary Human Keratinocytes from Adult Skin
Published on: December 22, 2017
17.2K
Keratinocyte: A trigger or an executor of psoriasis?
1Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China.
Journal of Leukocyte Biology
|March 15, 2020
Summary
This review highlights keratinocytes as potential psoriasis triggers, not just responders. It explores their role in maintaining chronic inflammation and disease relapse.
Area of Science:
- Dermatology
- Immunology
- Cell Biology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Immune cells, particularly the IL-23/IL-17 axis, are recognized drivers of psoriasis.
- The role of keratinocytes in psoriasis pathogenesis remains debated.
Purpose of the Study:
- To review recent findings identifying keratinocytes as triggers of psoriasis.
- To summarize keratinocyte involvement in sustaining psoriasis inflammation.
- To discuss keratinocyte contributions to psoriasis relapse.
Main Methods:
- Literature review of recent advances in psoriasis research.
- Analysis of studies focusing on keratinocyte function in psoriasis.
- Synthesis of evidence regarding keratinocyte-immune cell interactions.
Main Results:
- Emerging evidence suggests keratinocytes actively trigger psoriasis.
- Keratinocytes contribute to self-perpetuating inflammatory loops.
- Keratinocytes may play a significant role in psoriasis recurrence.
Conclusions:
- Keratinocytes are increasingly recognized as key players, potentially initiating psoriasis.
- Understanding keratinocyte roles is crucial for novel therapeutic strategies.
- Further research into keratinocyte-driven mechanisms may elucidate psoriasis relapse patterns.
Related Concept Videos
01:12Renewal of Skin Epidermal Stem Cells
2.9K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.9K
01:24T Cell Types and Functions
2.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.0K
01:24Cells of the Epidermis
6.5K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
6.5K
01:21Layers of the Epidermis
7.5K
The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
7.5K
01:30Skin Cancer
5.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
01:19Clinical Applications of Epidermal Stem Cells
3.1K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.1K