FSH signaling is involved in affective disorders
Wen-Kai Bi1, Si-Si Luan1, Jing Wang1
1Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicine, Ji-nan, 25000, China; School of Medicine, Shandong University, Ji-nan, 25000, China.
Abstract:
Affective disorders are a set of mental disorders and particularly disrupt the mental health of susceptible women during puberty, pregnancy, parturition and menopause transition, which are characterized by dramatic changes in reproductive hormone profiles. The serum FSH level changes significantly during these periods; yet, the role of FSH in mood regulation is poorly understood. In the current study, FSHR knockout (Fshr-/-) mice displayed enhanced affective disorder behaviors in an open field test and a forced swim test, accompanied by altered gene expression profiles. The differentially expressed genes between Fshr-/- mice and Fshr+/+ mice were enriched in multiple neuroendocrine metabolic pathways. FSHR deletion significantly increased/decreased the mRNA and/or protein expression levels of AOX1, RDH12, HTR3a and HTR4 in mood-mediating brain regions, including the hippocampus and prefrontal cortex. These results reveal that FSH signaling is involved in the development of affective disorders.
Related Concept Videos
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Testosterone: Functions and Regulation
G-protein Coupled Receptors
Neurotransmitters
Depressive Disorders: MDD and Dysthymia
Personality Disorders: Schizotypal and Histrionic
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...


