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[Generalized granuloma annulare: A clinicopathological study].
M Ehret1, C Lenormand1, J-N Scrivener1
1Clinique dermatologique, université de Strasbourg et hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.
Annales De Dermatologie Et De Venereologie
|March 16, 2020
Summary
Generalized granuloma annulare (GGA) frequently co-occurs with systemic diseases like dyslipidemia and diabetes. Screening for these conditions is recommended in patients with GGA due to its distinct associations.
Area of Science:
- Dermatology
- Pathology
- Internal Medicine
Background:
- Granuloma annulare (GA) is a benign skin condition, with generalized forms (GGA) occurring in 15% of cases.
- The association between GGA and systemic diseases is suggested by case reports but lacks robust evidence from large series.
- Clinical and histological features of GGA require further elucidation to understand its unique characteristics and associations.
Purpose of the Study:
- To describe the clinical and histological features of generalized granuloma annulare (GGA).
- To investigate the association between GGA and systemic diseases.
- To compare GGA with localized granuloma annulare.
Main Methods:
- Retrospective analysis of 35 biopsy-proven cases of generalized granuloma annulare (GGA) (≥10 lesions).
- Clinical data were extracted from patient medical files.
- Histological analysis focused on interstitial versus palisading patterns and eosinophil presence.
Main Results:
- The study included 35 patients with GGA (mean age 54 years, sex ratio 0.5).
- A high prevalence of associated systemic diseases was observed (77%), including dyslipidemia (27%), diabetes mellitus (20%), and autoimmune diseases (17%).
- Interstitial pattern was predominant histologically (54%), with frequent eosinophils (46%), unrelated to clinical type or systemic associations.
Conclusions:
- Generalized granuloma annulare (GGA) is significantly associated with systemic diseases, unlike localized GA.
- These associations appear uncorrelated with clinical or histological findings.
- Systematic screening for associated metabolic, infectious, or neoplastic diseases is warranted in GGA patients.
