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Dynamics of pertussis toxin IgG after symptomatic pertussis in children and adults

Piia Jõgi1, Hiie Soeorg2, Marje Oona3

  • 1Children's Clinic of Tartu University Hospital, Tartu, Estonia; Department of Pediatrics, University of Tartu, Tartu, Estonia.

Vaccine
|March 16, 2020
PubMed

Insights

Adults and children show distinct patterns in pertussis toxin IgG levels after infection. Understanding these pertussis dynamics is crucial for accurate diagnosis and management.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Pediatrics

Background:

  • Pertussis toxin IgG (PT-IgG) dynamics post-infection are not well understood.
  • Accurate diagnostic cut-off values for pertussis serology require further investigation.

Purpose of the Study:

  • To delineate the longitudinal changes in PT-IgG levels in children and adults up to three years after symptomatic pertussis.
  • To compare PT-IgG kinetics between pediatric and adult pertussis patients.

Main Methods:

  • Prospective enrollment of patients with persistent cough of unknown etiology.
  • Confirmation of pertussis via culture, PCR, and/or serology.
  • Serial PT-IgG measurements at 4-6 weeks, 1, 2, and 3 years post-enrollment, analyzed using a biexponential model.

Main Results:

  • Pertussis diagnosed in 22 patients (median age 17.7 years).
  • Adults exhibited higher PT-IgG peaks, longer time to peak, and shorter half-lives compared to children (p < 0.007).
  • Significant differences in PT-IgG kinetics were observed between age groups.

Conclusions:

  • Symptomatic pertussis leads to divergent PT-IgG dynamics in adults versus children.
  • These age-specific kinetics are important considerations for interpreting serological results in pertussis diagnosis.
Abstract

Keywords:
Biexponential modelPT-IgGPertussis toxinPower function decay model

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