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Related Concept Videos

Steps in Outbreak Investigation01:18

Steps in Outbreak Investigation

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In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
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Single Nucleotide Polymorphisms-SNPs01:05

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Principles of Disease Surveillance01:26

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Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
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Viral Mutations00:36

Viral Mutations

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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Viral Recombination00:57

Viral Recombination

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Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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Updated: Dec 26, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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The SARS-CoV-2 outbreak: What we know.

Di Wu1, Tiantian Wu2, Qun Liu1

  • 1Guangzhou Center for Disease Control and Prevention, Guangzhou, China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|March 16, 2020
PubMed
Summary
This summary is machine-generated.

The novel coronavirus Covid-19 (coronavirus disease 2019) outbreak rapidly spread globally. This paper consolidates key information on its epidemiology, clinical features, diagnosis, treatment, and prevention strategies.

Keywords:
Clinical featuresCoVID-19CoronavirusDiagnosisEpidemiologyManagements strategiesSARS-CoV-2Treatments

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Virology

Background:

  • A novel coronavirus, SARS-CoV-2 (previously 2019-nCoV), emerged in Wuhan, China, causing a worldwide Covid-19 outbreak.
  • As of March 2, 2020, the virus had spread to 6 continents and 66 countries, posing a significant global health challenge.
  • Effective outbreak control necessitates preparedness, transparency, and information sharing regarding epidemiology and clinical findings.

Purpose of the Study:

  • To aggregate and consolidate critical information on the Covid-19 pandemic.
  • To provide a comprehensive overview of SARS-CoV-2, including its epidemiology, clinical manifestations, diagnosis, treatment, and prevention.

Main Methods:

  • Literature review and data synthesis.
  • Consolidation of epidemiological data from outbreak sites.
  • Compilation of clinical information from diagnostic and research laboratories.

Main Results:

  • Detailed epidemiology of the SARS-CoV-2 outbreak.
  • Description of clinical manifestations associated with Covid-19.
  • Summary of current diagnostic approaches, treatment options, and preventive measures.

Conclusions:

  • The Covid-19 pandemic requires urgent global attention and coordinated control efforts.
  • Comprehensive understanding of the virus is essential for effective risk assessment and management.
  • This consolidated information serves as a vital resource for researchers, clinicians, and public health officials.