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Published on: December 17, 2021
Purulent infectious myositis (formerly tropical pyomyositis)
Miguel E Habeych1, Terry Trinh2, Nancy F Crum-Cianflone3
1Prince of Wales Clinical School, University of New South Wales (UNSW), Sydney, Australia.
Abstract:
Purulent infectious myositis (PIM), formerly known as tropical pyomyositis, is a pyogenic infection of skeletal muscles. Staphylococcus aureus, a normal human skin inhabitant, is the main pathogen involved, but multiple other microorganisms have been implicated. Although usually a progressive febrile disease with pain in the affected muscle(s), severe, life-threatening forms have been described, especially in immunosuppressed patients and children. PIM may elude early diagnosis given the lack of overlying skin changes. Hence, high index of suspicion followed by imaging modalities (ultrasonography when superficial and computed tomography or magnetic resonance imaging with contrast when deep) help confirm the diagnosis. Treatment requires combination of percutaneous or open surgical drainage along with antimicrobial therapy guided by culture results. The rising incidence of cases due to methicillin-resistant Staphylococcus aureus (MRSA) strains, makes the inclusion of vancomycin be recommended. This paper reviews PIM highlighting its global distribution, causative agents, predisposing factors, management, and potential complications.
Insights
Purulent infectious myositis (PIM) is a bacterial skeletal muscle infection, often caused by Staphylococcus aureus. Early diagnosis and treatment with drainage and antibiotics are crucial for managing this potentially severe condition.
Area of Science:
- Infectious Diseases
- Musculoskeletal Disorders
- Microbiology
Background:
- Purulent infectious myositis (PIM), previously tropical pyomyositis, is a pyogenic skeletal muscle infection.
- Staphylococcus aureus is the primary pathogen, though other microorganisms can be involved.
- PIM presents as a febrile illness with muscle pain, but can be severe, especially in immunocompromised individuals and children.
Purpose of the Study:
- To review purulent infectious myositis (PIM).
- Highlighting its global distribution, causative agents, predisposing factors, management, and potential complications.
Main Methods:
- Review of existing literature on PIM.
- Analysis of diagnostic imaging modalities.
- Evaluation of treatment strategies including antimicrobial therapy and surgical drainage.
Main Results:
- PIM diagnosis can be challenging due to subtle skin changes, necessitating a high index of suspicion.
- Imaging like ultrasonography, CT, and MRI are vital for diagnosis.
- Treatment involves surgical drainage and culture-guided antibiotics, with vancomycin recommended for MRSA strains.
Conclusions:
- Prompt diagnosis and appropriate management are essential for favorable outcomes in PIM.
- The increasing prevalence of MRSA necessitates updated treatment guidelines.
- Understanding PIM's epidemiology and risk factors aids in prevention and control efforts.
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