Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rate of decrease of myocardial O2 consumption due to cardiac arrest in anesthetized goats.

I Vergroesen1, J A Spaan

  • 1Department of Medical Physics, AMC, Amsterdam, The Netherlands.

Pflugers Archiv : European Journal of Physiology
|December 1, 1988
PubMed
Summary

Myocardial oxygen consumption (MVO2) rapidly decreases upon cardiac arrest. Changes in MVO2 precede alterations in venous oxygen content and coronary resistance, supporting interstitial oxygen

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coronary flow is not that simple!

Heart (British Cardiac Society)·2009
Same author

Evidence for stretch-induced resistance increase of proximal coronary microcirculation.

American journal of physiology. Heart and circulatory physiology·2001
Same author

Vasomotor effects of arg-gly-asp (RGD) peptides are limited and not related to endothelium-derived hyperpolarizing factor-mediated relaxation in rat mesenteric arteries.

Clinical and experimental pharmacology & physiology·2001
Same author

In vitro placental pressure-flow behaviour is non-linear and depends on the external pressure.

European journal of obstetrics, gynecology, and reproductive biology·2001
Same author

Role of Rho-associated protein kinase in tone and calcium sensitivity of cannulated rat mesenteric small arteries.

Experimental physiology·2001
Same author

Role of protein kinase C in myogenic calcium-contraction coupling of rat cannulated mesenteric small arteries.

Clinical and experimental pharmacology & physiology·2001

Area of Science:

  • Cardiovascular Physiology
  • Metabolic Regulation

Background:

  • Myocardial oxygen consumption (MVO2) is critical for cardiac function.
  • Understanding the dynamics of MVO2 during cardiac arrest is essential for elucidating regulatory mechanisms.

Purpose of the Study:

  • To measure the rate of change of MVO2 during the transition from beating to cardiac arrest.
  • To investigate the relationship between MVO2, venous oxygen content, and coronary resistance during cardiac arrest.

Main Methods:

  • Cardiac arrest was induced by destroying the bundle of His and interrupting pacing.
  • Coronary arterial and venous flows, and arterio-venous O2 content difference were continuously measured.
  • MVO2 transients were calculated using a 3-compartment model with analytical differentiation of fitted data.

Related Experiment Videos

Main Results:

  • MVO2 decreased significantly from 94 ± 5 to 15.4 ± 5 µLO2/s/100g within 15 seconds of cardiac arrest.
  • The reduction in MVO2 (50% in 3.8 s) occurred before changes in venous oxygen content (50% in 12.7 s) and coronary resistance (50% in 14.9 s).

Conclusions:

  • Interstitial oxygen concentration appears to be a primary determinant of coronary resistance.
  • The rapid decline in MVO2 suggests a direct link between cellular oxygen levels and vascular tone during ischemic events.