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Hydroxybutyl chitosan/diatom-biosilica composite sponge for hemorrhage control
Kaichao Zhang1, Jing Li1, Yanan Wang2
1College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, Shandong Province, China.
Carbohydrate Polymers
|March 17, 2020
Summary
A new hydroxybutyl chitosan and diatom-biosilica composite sponge (H-D) effectively controls bleeding. This advanced hemostatic material shows rapid absorption and significantly accelerates blood clotting for trauma treatment.
Area of Science:
- Biomaterials Science
- Hemostasis Research
- Trauma Medicine
Background:
- Effective bleeding control is crucial in trauma care.
- Current hemostatic agents have limitations in achieving desired outcomes.
Purpose of the Study:
- To develop and evaluate a novel composite sponge for enhanced hemorrhage control.
- To investigate the hemostatic efficacy of a hydroxybutyl chitosan and diatom-biosilica (H-D) composite.
Main Methods:
- Fabrication of a hierarchical porous composite sponge (H-D) using hydroxybutyl chitosan (HBC) and diatom-biosilica (DB).
- Assessment of biocompatibility through hemolysis ratio and cytotoxicity tests.
- Evaluation of fluid absorbability and in vitro coagulation performance, including clotting time and mechanism analysis.
Main Results:
- The H-D sponge demonstrated a hierarchical porous structure and excellent biocompatibility (hemolysis ratio < 5%, no cytotoxicity).
- It exhibited high and rapid fluid absorbability (11-16 times its weight).
- Significant hemostatic effect was observed, shortening clotting time by 70% compared to controls, due to erythrocyte aggregation and intrinsic pathway activation.
Conclusions:
- The H-D composite sponge shows significant potential as an effective material for hemorrhage control in trauma management.
- Its unique structure, biocompatibility, and rapid hemostatic properties make it a promising candidate for clinical applications.
