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Atrial fibrillation in chronic heart failure patients with reduced ejection fraction: The CHECK-HF registry

Jesse F Veenis1, Hans-Peter Brunner-La Rocca2, Gerard C M Linssen3

  • 1Erasmus MC, University Medical Center Rotterdam, Thorax Center, Department of Cardiology, Rotterdam, the Netherlands.

International Journal of Cardiology
|March 17, 2020
PubMed

Insights

Atrial fibrillation (AF) is common in heart failure (HF) patients, influencing treatment. This study found significant differences in guideline-recommended HF therapy prescriptions between patients with and without AF.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Pharmacology

Background:

  • Atrial fibrillation (AF) is a prevalent comorbidity in patients with chronic heart failure (HF).
  • AF significantly impacts therapeutic strategies and patient outcomes in HF management.
  • Understanding AF's influence on HF treatment is crucial for optimizing patient care.

Purpose of the Study:

  • To investigate the impact of atrial fibrillation (AF) on the prescription patterns of guideline-recommended therapies in patients with chronic heart failure with reduced ejection fraction (HFrEF).
  • To compare the utilization of specific HF medications between HFrEF patients with and without AF.

Main Methods:

  • Analysis of a large real-world HF registry including 8253 patients with chronic HFrEF.
  • Data collected from 34 Dutch outpatient clinics between 2013 and 2016, adhering to 2012 ESC guidelines.
  • Comparison of medication prescriptions between patients with AF (n=2109) and without AF (n=6144).

Main Results:

  • Patients with AF were more frequently prescribed beta-blockers, MRAs, diuretics, and digoxin compared to those without AF.
  • Conversely, patients with AF received renin-angiotensin-system (RAS)-inhibitors less frequently.
  • The proportion of patients receiving guideline-recommended HF therapies at target doses was similar between AF and non-AF groups.

Conclusions:

  • A high prevalence of AF was observed in chronic HFrEF patients.
  • Significant disparities exist in the prescription of guideline-recommended HF therapies based on AF status.
  • These findings highlight the need for tailored therapeutic approaches in HFrEF patients with AF.
Abstract

Keywords:
Atrial fibrillationGuideline adherenceHFrEFHeart failureTreatment

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