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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

1.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Transcytosis of IgG01:15

Transcytosis of IgG

3.9K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
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Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Related Experiment Video

Updated: Dec 26, 2025

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

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Pregnancy and autoimmune diseases.

Emily C Somers1

  • 1University of Michigan Schools of Medicine & Public Health, Departments of Internal Medicine, Environmental Health Sciences and Obstetrics and Gynecology, 2800 Plymouth Rd, NCRC B14-G236, Ann Arbor, MI 48109-2800, USA.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|March 17, 2020
PubMed
Summary

Women with autoimmune diseases (AID) need multidisciplinary care for reproductive health optimization. Family planning and specialized contraception are crucial for managing AID during pregnancy and improving maternal and fetal outcomes.

Keywords:
Autoimmune diseasesPreconception carePregnancyReproductive healthRheumatoid arthritisSystemic lupus erythematosus

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Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
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Area of Science:

  • Reproductive immunology
  • Autoimmune disease management
  • Women's health

Background:

  • Autoimmune diseases (AID) disproportionately affect women.
  • Pregnancy-associated factors like hormonal changes and fetal microchimerism may impact maternal AID risk.
  • Optimizing reproductive health for women with AID requires proactive, integrated care.

Purpose of the Study:

  • To outline essential reproductive health strategies for women with autoimmune diseases.
  • To emphasize the importance of family planning and contraception in managing AID.
  • To highlight the benefits of multidisciplinary care for maternal and fetal outcomes.

Main Methods:

  • Review of current literature on autoimmune diseases, pregnancy, and reproductive health.
  • Analysis of factors influencing AID risk and management in women.
  • Emphasis on multidisciplinary care models and treatment considerations.

Main Results:

  • Family planning allows for pregnancy timing during stable disease phases and medication adjustment.
  • Contraception choices must consider specific AID and laboratory findings.
  • Fertility preservation options are important for females undergoing gonadotoxic therapy.
  • Multispecialty care and monitoring optimize maternal and fetal outcomes during pregnancy and postpartum.

Conclusions:

  • Comprehensive, multidisciplinary care is vital for women with AID throughout their reproductive lives.
  • Proactive family planning, appropriate contraception, and compatible treatment regimens are key.
  • Optimized maternal and fetal outcomes are achievable with sustained, specialized care.