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Clinical outcome measures in multiple sclerosis: A review
Hernan Inojosa1, Dirk Schriefer1, Tjalf Ziemssen1
1MS Center, Center of Clinical Neuroscience, Carl Gustav Carus University Clinic, Fetscherstr. 74, 01307 Dresden, Germany.
Autoimmunity Reviews
|March 17, 2020
Summary
Evaluating Multiple Sclerosis (MS) progression requires robust clinical outcome measures (COMs). This review examines current and emerging COMs for MS, focusing on their ability to detect disease changes and treatment response.
Area of Science:
- Neurology
- Clinical Research
- Medical Technology
Background:
- Accurate assessment of Multiple Sclerosis (MS) progression is crucial for patient care and therapeutic development.
- Clinical Outcome Measures (COMs) standardize disease characterization, requiring good validity, reliability, and responsiveness.
- The Expanded Disability Status Scale (EDSS) is the primary tool, but other COMs exist and newer digital tools are emerging.
Purpose of the Study:
- To review established and novel Clinical Outcome Measures (COMs) for assessing Multiple Sclerosis (MS) progression.
- To evaluate the responsiveness of these COMs in detecting clinically relevant changes and treatment effects.
- To discuss operationalization, statistical considerations, and future digital tools for MS assessment.
Main Methods:
- Systematic literature review of Clinical Outcome Measures (COMs) used in Multiple Sclerosis (MS) research and clinical practice.
- Analysis of psychometric properties, focusing on validity, reliability, and responsiveness of each COM.
- Inclusion of newer composite COMs and emerging digital assessment tools.
Main Results:
- The Expanded Disability Status Scale (EDSS) remains the most common measure for MS disability.
- Several other COMs exist with varying strengths in assessing MS progression.
- Emerging composite COMs and digital tools show promise for enhanced responsiveness and data collection.
Conclusions:
- A comprehensive understanding of various COMs is essential for effective Multiple Sclerosis (MS) management.
- Focusing on COM responsiveness is key to identifying disease progression and treatment efficacy.
- Future research should explore the integration of novel composite and digital COMs into clinical practice.
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