Related Experiment Video

Updated: Dec 26, 2025

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
10:13

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells

Published on: July 3, 2013

11.5K

Cancer vaccines: Targeting KRAS-driven cancers

Ying Zhang1, Jin-An Ma1, Hai-Xia Zhang1

  • 1Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China.

Expert Review of Vaccines
|March 17, 2020
PubMed

Insights

KRAS mutation-based cancer vaccines show promise for treating cancers by targeting tumor-specific neo-antigens. Combining these vaccines with other therapies may overcome tumor suppression and improve success rates.

Area of Science:

  • Oncology
  • Immunology
  • Vaccinology

Background:

  • Mutant KRAS is a key driver in many cancers, posing a significant therapeutic challenge.
  • Neo-antigens from KRAS mutations are tumor-specific and highly immunogenic, making them targets for precision cancer vaccines.
  • KRAS mutation-based vaccines have shown encouraging preclinical and clinical results.

Purpose of the Study:

  • To review the development and progress of vaccines targeting KRAS.
  • To evaluate the potential benefits and obstacles of KRAS-targeted vaccines in treating KRAS-driven cancers.

Main Methods:

  • Literature review of studies on KRAS mutation-based cancer vaccines.
  • Analysis of preclinical and clinical data regarding vaccine efficacy.
  • Evaluation of factors influencing vaccine immunogenicity and therapeutic outcomes.

Main Results:

  • KRAS mutation-based cancer vaccines can elicit an immune response in patients.
  • Tumor microenvironment factors can impede vaccine efficacy.
  • Combining vaccines with other therapies and adjuvants shows potential to enhance anti-tumor responses.

Conclusions:

  • KRAS mutation-targeted cancer vaccines are a promising therapeutic strategy.
  • Overcoming tumor immunosuppression is crucial for maximizing vaccine effectiveness.
  • Combination therapies hold potential for successful treatment of KRAS-driven cancers.
Keywords:
KRAS mutationcolorectal cancerlung cancerneo-antigen vaccinepancreatic cancerpeptide vaccine

More Related Videos

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System05:45

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System

Published on: January 9, 2020

8.3K
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

18.5K

Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
878
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.9K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.0K