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Related Experiment Videos

Behavioral indications for serotonin receptor hypersensitivity in panic disorder.

R S Kahn1, S Wetzler, H M van Praag

  • 1Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 10467.

Psychiatry Research
|July 1, 1988
PubMed
Summary

Patients with panic disorder exhibit heightened anxiety and panic attacks when given m-chlorophenylpiperazine (MCPP), a serotonin agonist. This suggests a hypersensitive serotonin system in panic disorder, unlike in depression or normal controls.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Serotonin pathways are implicated in mood and anxiety disorders.
  • Selective serotonin agonists can elicit behavioral changes.

Purpose of the Study:

  • To investigate the behavioral effects of m-chlorophenylpiperazine (MCPP) in patients with panic disorder compared to controls.
  • To explore the role of serotonin receptor sensitivity in panic disorder.

Main Methods:

  • Administered MCPP, a selective serotonin agonist, to normal controls, patients with panic disorder, and patients with major depression.
  • Recorded placebo-corrected behavioral responses.

Main Results:

  • Panic disorder patients showed increased anxiety, depression, and hostility.

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  • 60% of panic disorder patients experienced panic attacks.
  • Normal controls and depressed patients did not exhibit significant behavioral changes.

    • Conclusions:

    • Panic disorder patients may possess a hypersensitive postsynaptic serotonin receptor system.
    • Serotonin system dysregulation is a potential factor in panic disorder pathophysiology.