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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
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Proton beam therapy for liver cancers.
Michael Chuong1, Adeel Kaiser2, Jason Molitoris2
1Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, USA.
Journal of Gastrointestinal Oncology
|March 17, 2020
Summary
Proton beam therapy (PBT) offers a safer alternative for liver cancer treatment by reducing radiation dose to healthy organs. This approach shows promise for excellent tumor control with minimal side effects in various liver cancer types.
Area of Science:
- Radiation Oncology
- Hepatobiliary Cancers
Background:
- Radiation-induced liver disease (RILD) is a significant concern in liver cancer treatment.
- Liver dose is a critical factor predicting RILD.
- Proton beam therapy (PBT) spares normal tissues more effectively than X-ray therapy (XRT).
Purpose of the Study:
- To evaluate the efficacy and safety of PBT for liver cancers.
- To highlight PBT's advantages in minimizing dose to normal liver tissue.
Main Methods:
- Review of existing data on PBT for liver cancers.
- Comparison of dose distribution between PBT and XRT.
Main Results:
- High-dose PBT demonstrates excellent long-term tumor control in hepatocellular carcinoma (HCC).
- PBT shows minimal toxicity in HCC patients.
- Ablative PBT is increasingly supported for unresectable cholangiocarcinoma and liver metastases, particularly for larger tumors.
Conclusions:
- PBT is a viable and effective treatment for various liver cancers.
- PBT's dose-sparing capability makes it advantageous for liver tumors, reducing RILD risk.
