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Updated: Dec 26, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Aortic valve replacement using valve-in-valve procedure in a patient with left atrial appendage thrombus
Mehmet Erdoğan1, Engin Bozkurt2
1Department of Cardiology, Ankara City Hospital, Ankara, Turkey.
Insights
Transcatheter aortic valve replacement (TAVR) is increasingly used in older patients. This study demonstrates that valve-in-valve TAVR is feasible even with a left atrial appendage thrombus, a common exclusion criterion.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Transcatheter aortic valve replacement (TAVR) indications and patient eligibility are expanding.
- Left atrial appendage (LAA) thrombus is typically an exclusion criterion for TAVR studies.
- Degeneration of bioprosthetic aortic valves necessitates reintervention.
Observation:
- An 86-year-old male presented with severe aortic stenosis due to a degenerated bioprosthetic valve.
- Transesophageal echocardiography and contrast-enhanced CT confirmed an LAA thrombus.
- The patient had a 22-mm bioprosthetic valve implanted 14 years prior.
Findings:
- Successful valve-in-valve TAVR was performed despite the presence of an LAA thrombus.
- A balloon-expandable valve was implanted into the degenerated bioprosthetic aortic valve.
- This case highlights the potential for TAVR in complex scenarios.
Implications:
- Valve-in-valve TAVR may be a viable option for patients with LAA thrombus.
- This challenges current exclusion criteria in TAVR research.
- Further studies are warranted to assess the safety and efficacy of TAVR in patients with LAA thrombi.
Abstract:
In recent years, indications and age range of patients who are eligible for transcatheter aortic valve replacement have been increasingly extended. The presence of a thrombus in the left atrial appendage is an exclusion criterion in many studies using transcatheter aortic valve replacement. An 86-year-old male patient was admitted with symptomatic severe aortic stenosis secondary to degeneration of a 22-mm bioprosthetic valve implanted 14 years ago. Transesophageal echocardiography revealed a thrombus in the left atrial appendage and it was confirmed by contrast-enhanced computed tomography. The balloon-expandable valve was successfully implanted into the degenerated aortic bioprosthesis. In conclusion, we aimed to show that valve-in-valve transcatheter aortic valve replacement can be performed in a patient with thrombus in the left atrial appendage.
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