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Electrically Conducting Hydrogel Graphene Nanocomposite Biofibers for Biomedical Applications
Sepehr Talebian1,2, Mehdi Mehrali3, Raad Raad4
1Intelligent Polymer Research Institute, University of Wollongong, Wollongong, NSW, Australia.
Frontiers in Chemistry
|March 17, 2020
Summary
Researchers developed flexible, conductive biofibers from alginate and graphene for cell stimulation. These biocompatible fibers show promise for tissue engineering scaffolds.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Conductive biomaterials are crucial for electrical stimulation of excitable cells.
- Alginate and graphene are promising components for advanced biomaterials.
- Developing robust, conductive, and biocompatible materials is an ongoing challenge.
Purpose of the Study:
- To create flexible, electrically conducting fibers using alginate and graphene.
- To evaluate the mechanical, electrical, and electrochemical properties of these nanocomposite fibers.
- To assess the biocompatibility of the novel biofibers with C2C12 myoblast cell lines.
Main Methods:
- Wet-spinning process utilized to fabricate alginate-graphene nanocomposite fibers.
- Mechanical, electrical, and electrochemical characterization of the fibers.
- In vitro studies using C2C12 myoblast cell lines to evaluate biocompatibility.
Main Results:
- Nanocomposite fibers exhibited superior mechanical, electrical, and electrochemical properties compared to alginate-only fibers.
- In vitro studies confirmed the biocompatibility of the conductive biofibers with C2C12 myoblasts.
- The developed fibers are flexible, electrically conducting, and robust.
Conclusions:
- Alginate-graphene nanocomposite fibers are a promising conductive biomaterial.
- These biofibers demonstrate excellent biocompatibility for cellular applications.
- The developed hybrid conductive biofibers are suitable for 3D scaffolding in tissue engineering.
