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Updated: Dec 26, 2025

Comparing the Affinity of GTPase-binding Proteins using Competition Assays
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Recent Advances in Understanding Biological GTP Hydrolysis through Molecular Simulation

Ana Rita Calixto1, Cátia Moreira1, Shina Caroline Lynn Kamerlin1

  • 1Department of Chemistry - BMC, Uppsala University, BMC Box 576, S-751 23 Uppsala, Sweden.

ACS Omega
|March 17, 2020
PubMed
Summary

GTP hydrolysis, essential for cellular processes, remains mechanistically debated. Recent computational studies suggest solvent-assisted hydrolysis is a conserved mechanism across GTPases, impacting drug discovery and cancer research.

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