Association between intercellular adhesion molecule 1 (ICAM1) polymorphisms and diabetic foot susceptibility: A...

Area of Science:

• Genetics
• Endocrinology
• Immunology

Background:

• Diabetic foot (DF) is a severe complication of type 2 diabetes mellitus (T2DM).
• Intercellular adhesion molecule 1 (ICAM1) plays a role in inflammation and immune responses, potentially influencing DF development.
• Genetic variations in ICAM1 may affect susceptibility to T2DM and its complications like DF.

Purpose of the Study:

• To investigate the association between ICAM1 polymorphisms (rs5498 and rs3093030) and the risk of developing diabetic foot (DF) in a Chinese Han population.
• To explore the correlation between these ICAM1 polymorphisms and clinical characteristics of DF patients.

Main Methods:

• Case-control study involving 128 T2DM patients with DF, 147 T2DM patients without DF, and 155 healthy controls.
• Genotyping of ICAM1 rs5498 and rs3093030 polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
• Statistical analysis including chi-square tests, odds ratios (OR) with 95% confidence intervals (95%CI), and t-tests to compare genotypes, alleles, and clinical data.

Main Results:

• The GG genotype of rs5498 was associated with a decreased risk of T2DM and reduced DF susceptibility in healthy individuals.
• The G allele of rs5498 also showed a protective effect against T2DM and DF in healthy controls.
• Carrying the T allele of rs3093030 was linked to lower susceptibility to DF in T2DM patients.
• DF patients with the rs5498 AA genotype had significantly higher serum creatinine levels compared to GG genotype carriers.

Conclusions:

• ICAM1 rs3093030 polymorphism may serve as a protective factor against diabetic foot development in T2DM patients.
• ICAM1 rs5498 polymorphism might be involved in the onset of type 2 diabetes mellitus.
• Genetic variations in ICAM1 could influence the risk and clinical presentation of diabetic foot.