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Giant fibrous hamartoma of infancy: A case report
Sun Wang1, Qichao Ma1, Hao Ying1
1Department of Orthopedics, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Insights
This case report details the largest fibrous hamartoma of infancy (FHI) in a child, successfully treated with amputation. The rare soft-tissue tumor showed no recurrence after 6 years, indicating a favorable prognosis with aggressive intervention.
Area of Science:
- Pediatric oncology
- Surgical pathology
- Rare tumor research
Background:
- Fibrous hamartoma of infancy (FHI) is a rare benign soft-tissue tumor in children.
- Characterized by a triphasic organoid histologic appearance.
Rationale:
Fibrous hamartoma of infancy (FHI) is a rare benign soft-tissue tumor in children with a triphasic organoid histologic appearance.
Patient Concerns:
We here report a case with the largest FHI published so far. A 13-month-old boy with a rapidly growing tumor 45 cm in length and 69.3 cm in circumference of the left lower extremity was identified immediately at birth.
Diagnoses:
The diagnosis was uncertain before the operation, although biopsy was conducted. The postoperation histological examination showed arranged spindle cells, adipose tissue, and nests of immature small cells embedded in a myxoid background, which is the characteristic triphasic histology of FHI.
Interventions:
Under general anesthesia, hip and lower extremity amputation was performed.
Outcomes:
The patient was followed-up for 6 years and no signs of recurrence were found, suggesting a favorable prognosis, although a part of the residual tumor was present after the surgery.
Lessons:
FHI exhibits pathological and clinical characteristics. However, differential diagnosis of FHI from other soft-tissue tumors before operation remains a challenge. Thus, sometimes, aggressive therapy for the treatment of FHI might be a good choice to get a satisfactory.
