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Updated: Dec 26, 2025
05:05
Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
863
A Systematic Review of Drug-Induced Pemphigoid
Matthew J Verheyden1, Asli Bilgic, Dédée F Murrell
1School of Medicine, University of Notre Dame, Sydney, Australia.
Acta Dermato-Venereologica
|March 17, 2020
Summary
Drug-associated bullous pemphigoid (DABP) is linked to 89 medications, with gliptins and PD-1/PD-L1 inhibitors showing strong associations. Identifying these drugs aids earlier diagnosis and treatment of this autoimmune skin condition.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Bullous pemphigoid is an autoimmune subepithelial blistering disease.
- Drug-associated bullous pemphigoid (DABP) mimics idiopathic bullous pemphigoid but is linked to specific drug exposures.
Purpose of the Study:
- To systematically review and identify drugs implicated in drug-associated bullous pemphigoid.
- To provide clinicians with a comprehensive list of medications linked to DABP.
Main Methods:
- A comprehensive literature search was conducted adhering to PRISMA guidelines.
- 170 publications were included in the final qualitative analysis.
Main Results:
- A total of 89 drugs were identified as being implicated in DABP.
- Strongest evidence for DABP association was found with gliptins, PD-1/PD-1 inhibitors, loop diuretics, and penicillin derivatives.
Conclusions:
- Awareness of medications associated with bullous pemphigoid facilitates earlier identification and management of DABP.
- Prompt cessation of the offending drug is crucial for managing DABP.
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