Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Liposomal Vitamin C as a Modulator of the Efficacy of Ceralasertib Therapy in Ovarian Cancer.

International journal of molecular sciences·2026

Same author

Next-generation diabetes diagnostics: spectrochemical staging of red blood cells using vibrational spectroscopy.

Journal of advanced research·2026

Same author

The role of Themis in development of type 2 diabetes.

Research square·2025

Same author

Molecular mechanisms and computational insights into human SGLTs: advancing toward selective SGLT1 inhibition.

Frontiers in molecular biosciences·2025

Same author

Intermittent fasting in the treatment of type 2 diabetes.

Frontiers in nutrition·2025

Same author

PAXX/Ku interaction is rate limiting for repair of double-strand DNA breaks requiring end processing.

The Journal of biological chemistry·2025

Search research articles

Related Experiment Video

Updated: Dec 26, 2025

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

Mechanical Properties Determination of DMPC, DPPC, DSPC, and HSPC Solid-Ordered Bilayers.

Dominik Drabik¹, Grzegorz Chodaczek², Sebastian Kraszewski¹

¹Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, Pl. Grunwaldzki 13, 50-377 Wrocław, Poland.

Langmuir : the ACS Journal of Surfaces and Colloids

|March 17, 2020

Summary

Solid lipid bilayers exhibit unique mechanical properties. Contrary to expectations, their bending rigidity decreases with increasing lipid transition temperature in vesicles, unlike planar systems, offering insights into membrane behavior.

More Related Videos

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Published on: January 3, 2018

Related Experiment Videos

Last Updated: Dec 26, 2025

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions

Published on: August 3, 2021

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Fabrication Procedures and Birefringence Measurements for Designing Magnetically Responsive Lanthanide Ion Chelating Phospholipid Assemblies

Published on: January 3, 2018

Area of Science:

Biophysics
Materials Science
Cell Biology

Background:

Lipid bilayers exist in liquid and solid phases, with solid phases (crystalline, gel) offering mechanical resilience.
Solid lipid phases are crucial for cell membrane dynamics and drug delivery systems.
Understanding solid phase mechanical properties is key for biological and technological applications.

Purpose of the Study:

Investigate the structural and mechanical properties of solid lipid bilayers in vesicles.
Determine the effect of lipid transition temperature on bilayer properties.
Compare mechanical properties between spherical vesicles and planar lipid systems.

Main Methods:

Atomistic molecular dynamics simulations of whole vesicles.
Measurement of area per lipid, membrane thickness, and area compressibility.
Flicker noise spectroscopy to determine bending rigidity coefficient.

Main Results:

Bending rigidity coefficient decreased with increasing lipid transition temperature in solid-ordered vesicles, contrary to planar systems.
Membrane thickness and area compressibility increased with lipid transition temperature.
Area per lipid decreased with increasing lipid transition temperature.

Conclusions:

Solid lipid bilayers in vesicles exhibit distinct mechanical behaviors compared to planar systems.
The study provides valuable mechanical insights into the behavior of lipid bilayers in solid phases.
Findings are relevant for understanding membrane dynamics and designing lipid-based drug delivery systems.