Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

1.2K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.2K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

272
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
272
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.2K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.2K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

4.5K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.5K
Lipid Absorption01:24

Lipid Absorption

2.3K
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
2.3K
Gallbladder01:17

Gallbladder

1.8K
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uric acid to high density lipoprotein-cholesterol ratio as a potential biomarker of comorbidities in youth with obesity.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2026
Same author

A Pilot Real-life Study Opioid Induced Constipation in Neoplastic Patients Admitted to Internal Medicine Ward. Outcome of Naldemedine Therapy According to Available Guidelines.

Journal of gastrointestinal and liver diseases : JGLD·2026
Same author

Targeting the Human Gut Microbiota-Between Conventional Therapy and Precision Genetic Engineering.

Nutrients·2026
Same author

Practical approach to the diagnosis, management, and treatment of pediatric patients with bone fragility: an expert opinion.

Journal of endocrinological investigation·2026
Same author

Improvements in screening test, diagnosis, and outcomes of children with congenital hypothyroidism: lessons learned from 50 years of newborn screening.

Endocrine·2026
Same author

Dietary Fructose Alters Duodenal Mucin Glycosylation and Mucus Production in High-Fat Diet-Fed Mice.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Dec 26, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.0K

Physical Activity Modulating Lipid Metabolism in Gallbladder Diseases.

Harshitha Shanmugam1, Emilio Molina Molina2, Domenica Maria Di Palo3

  • 1Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy. . harshitha.shanmugam@uniba.it.

Journal of Gastrointestinal and Liver Diseases : JGLD
|March 17, 2020
PubMed
Summary

Regular physical activity offers broad health benefits, including positive impacts on the hepatobiliary tract. Exercise influences lipid metabolism, gallbladder function, and bile acid circulation, affecting metabolic inflammation.

More Related Videos

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

4.6K
Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
07:59

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

Published on: July 21, 2017

10.0K

Related Experiment Videos

Last Updated: Dec 26, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.0K
Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

4.6K
Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads
07:59

Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

Published on: July 21, 2017

10.0K

Area of Science:

  • Integrative physiology and metabolic health research.
  • Focus on the hepatobiliary system's response to exercise.

Background:

  • Physical activity is known to benefit cardiovascular and metabolic health.
  • Emerging research highlights the hepatobiliary tract as a key area affected by exercise.
  • Understanding these effects is crucial for managing metabolic disorders.

Purpose of the Study:

  • To provide a global overview of physical activity's effects on the hepatobiliary tract.
  • To examine the relationship between exercise (modality, intensity) and gallbladder health.
  • To explore impacts on lipid metabolism, bile acid circulation, and inflammation.

Main Methods:

  • Systematic review and synthesis of existing research on physical activity and the hepatobiliary system.
  • Analysis of studies correlating exercise parameters with metabolic and gallbladder outcomes.
  • Examination of data on gallbladder motor function and enterohepatic circulation.

Main Results:

  • Physical activity influences lipid metabolism and systemic metabolic inflammation.
  • Exercise affects gallbladder diseases, including gallstones, symptoms, and quality of life.
  • Modality and intensity of exercise play a role in hepatobiliary outcomes.

Conclusions:

  • Physical activity has multifaceted effects on the hepatobiliary tract and overall metabolic health.
  • Further research is needed to elucidate the precise pathophysiological mechanisms.
  • Tailoring exercise interventions may optimize benefits and mitigate risks in diverse metabolic conditions.