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Biotherapeutic Approaches in Atopic Dermatitis
Elizabeth Huiwen Tham1,2, Elvin Koh3,4, John E A Common5
1Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Biotechnology Journal
|March 17, 2020
Summary
New biotherapies aim to restore a healthy skin microbiome for atopic dermatitis (AD) by removing Staphylococcus aureus. Further research is needed to optimize these microbiome-based interventions for clinical practice.
Area of Science:
- Dermatology
- Microbiology
- Immunology
Background:
- The skin microbiome is crucial in inflammatory skin disorders like atopic dermatitis (AD).
- Dysbiosis in AD involves an imbalance between Staphylococcus aureus (S. aureus) and beneficial skin symbionts, leading to immune dysregulation and impaired skin barrier function.
Purpose of the Study:
- To explore emerging biotherapeutic strategies for AD prevention and management.
- To harness the skin microbiome for therapeutic benefit by restoring symbionts and reducing S. aureus.
Main Methods:
- Review of current biotherapeutic strategies including microbiome transplants, phage endolysins, monoclonal antibodies, and quorum sensing inhibitors.
- Focus on restoring a diverse symbiotic skin microbiome while selectively eliminating pathogenic S. aureus.
Main Results:
- Emerging biotherapeutic strategies show promise for AD management.
- These strategies aim to re-establish a healthy skin microbiome equilibrium.
Conclusions:
- Further research is essential to optimize microbiome-based interventions for AD.
- Key areas for investigation include understanding microbiome community dynamics, patient selection, drug delivery, treatment duration, and overcoming recolonization to enable clinical adoption.
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