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Rethinking furosemide use for infants with bronchopulmonary dysplasia

Jeffrey L Segar1

  • 1Division of Neonatology, Departments of Pediatrics and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Pediatric Pulmonology
|March 17, 2020
PubMed

Insights

Diuretics like furosemide are used for infants with bronchopulmonary dysplasia (BPD), but long-term benefits lack prospective data. Understanding furosemide

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Pharmacology

Background:

  • Diuretics, specifically furosemide, are frequently used in infants with bronchopulmonary dysplasia (BPD) to enhance respiratory outcomes.
  • The long-term efficacy and safety of diuretic use in BPD remain incompletely understood, lacking robust prospective data.
  • While adverse effects of furosemide are recognized, a comprehensive understanding of its impact on infant pathophysiology is needed.

Purpose of the Study:

  • To highlight the common use of diuretics in infants with BPD.
  • To emphasize the need for a deeper understanding of furosemide's effects.
  • To encourage clinicians to consider potential complications of furosemide administration.

Main Methods:

  • Review of existing literature on diuretic use in BPD.
  • Analysis of known pathophysiological impacts of furosemide.
  • Discussion of implications for clinical practice.

Main Results:

  • Prospective data on long-term benefits of diuretics in BPD are absent.
  • Furosemide has known adverse effects, but its full impact requires further investigation.
  • Understanding the effects on sodium metabolism and cardiopulmonary physiology is crucial.

Conclusions:

  • Furosemide likely plays a role in managing BPD in infants.
  • Clinicians should be aware of and monitor for potential complications.
  • Further research is required to elucidate the complex effects of diuretics in BPD.

Keywords:
aldosteroneangiotensinbronchopulmonary dysplasiafurosemideneonate

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