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Related Experiment Videos

Trace element alterations in infectious diseases.

U Srinivas1, J H Braconier, B Jeppsson

  • 1Department of Clinical Chemistry, Lund University, Sweden.

Scandinavian Journal of Clinical and Laboratory Investigation
|October 1, 1988
PubMed
Summary

Plasma trace element levels, including selenium and zinc, decrease significantly during acute bacterial and viral infections. These non-specific changes are linked to inflammation and can persist for weeks, impacting immune function.

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Area of Science:

  • Biochemistry
  • Immunology
  • Clinical Medicine

Background:

  • Trace elements like copper, zinc, iron, and selenium are crucial for immune system function.
  • Altered trace element levels are observed in various disease states, including infections.

Purpose of the Study:

  • To investigate plasma trace element concentrations in patients with acute bacterial and viral infections.
  • To compare trace element level changes between bacterial and viral infections and correlate them with inflammatory markers.

Main Methods:

  • Analysis of plasma levels of copper, zinc, iron, and selenium in 53 patients with acute bacterial or viral infections.
  • Comparison of trace element levels with healthy controls and assessment of changes over time.

Main Results:

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  • Bacterial infections (sepsis, pneumonia) showed decreased plasma selenium, iron, and zinc. Copper levels increased, except in erysipelas.
  • Viral infections exhibited similar but less pronounced trace element shifts compared to bacterial infections.
  • Significant reductions in plasma selenium and zinc were observed in bacterial infections, particularly sepsis and pneumonia, compared to viral infections.

Conclusions:

  • Acute bacterial and viral infections cause significant, non-specific alterations in plasma trace element concentrations.
  • These changes, particularly in selenium and zinc, are more pronounced in bacterial infections and associated with inflammatory responses.
  • The observed trace element shifts are transient, appearing within days and lasting for weeks, independent of the specific infectious agent.