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Development of the second generation Japanese encephalitis (JE) vaccine
1Department of Virology, Nagasaki University, Japan.
The Southeast Asian Journal of Tropical Medicine and Public Health
|September 1, 1988
Abstract:
Recent analysis of Japanese encephalitis (JE) virus genome RNA, especially its nucleotide sequence, revealed the localization of virion envelope glycoprotein (E) gene on the virus genome. Since the E protein is the major protective antigen related with the virus neutralization, attempts have been made to produce the second generation JE vaccine by expressing the E protein using recombinant DNA technologies. These studies will eventually lead to control JE by mass-vaccination in several Asian countries where JE is one of the major public health problems.