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Antiviral Drug Discovery and Development for Mayaro Fever - What do we have so far?

Marcos V P Mello1,2, Thaisa F S Domingos1, Davis F Ferreira3,4

  • 1Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Mini Reviews in Medicinal Chemistry
|March 18, 2020
PubMed

Insights

Mayaro virus (MAYV) causes Mayaro fever, a disease with symptoms similar to Dengue and Zika. New antiviral drugs are urgently needed as no vaccine or treatment currently exists for MAYV.

Area of Science:

  • * Tropical infectious diseases and emerging viral threats.
  • * Virology and arbovirus research.
  • * Drug discovery and development for infectious diseases.

Background:

  • * Mayaro virus (MAYV) is an emerging arbovirus responsible for Mayaro fever, prevalent in tropical regions.
  • * Mayaro fever symptoms (fever, headache, arthralgia, rash) overlap with other arboviruses like Dengue, Zika, and Chikungunya, complicating diagnosis.
  • * MAYV poses a significant threat for large-scale epidemics, similar to Zika virus (ZIKV) and Chikungunya virus (CHIKV).

Purpose of the Study:

  • * To review existing studies on anti-MAYV derivatives.
  • * To emphasize the critical need for novel antiviral drug candidates against Mayaro fever.
  • * To highlight the potential of MAYV as a significant public health concern.

Main Methods:

  • * Mini-review of published literature on anti-MAYV research.
  • * Analysis of studies focusing on potential antiviral compounds against MAYV.
  • * Synthesis of current knowledge on Mayaro fever therapeutics.

Main Results:

  • * Limited development of specific antiviral treatments for Mayaro fever.
  • * Identification of research gaps in anti-MAYV drug discovery.
  • * Highlighting the urgent need for further investigation into antiviral derivatives.

Conclusions:

  • * There is a critical lack of licensed vaccines or antiviral treatments for Mayaro fever.
  • * The development of effective antiviral drugs against MAYV is urgently required.
  • * Further research into anti-MAYV derivatives is essential to combat potential epidemics.
Keywords:
Mayaro virusalphavirusantiviralsarbovirusesmayaro fevertropical infectious.

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